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The major components of a guardrail system are crucial for ensuring safety on construction sites and other elevated work areas. Guardrail systems are designed to prevent falls from heights and to provide protection for workers engaged in tasks near open edges or platforms.

The correct answer encompasses a comprehensive view of the necessary elements that make up an effective guardrail system. These components include the top rail, which provides the primary level of protection, a mid-rail for added safety to prevent a person's body from falling through, and toe boards that stop materials and tools from falling off the edge. Additionally, screens can be included to prevent objects from falling while also protecting workers below from debris.

This answer reflects a complete understanding of guardrail systems in construction, recognizing that each component plays a specific role in maintaining safety and compliance with regulations. When all components are properly integrated, they provide a robust system that significantly reduces the risk of falls and injuries, demonstrating the importance of a multi-faceted approach to safety.